34 articles - From Friday Sep 23 2022 to Friday Sep 30 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
Association of visceral adipose tissue with postoperative outcome in upper gastrointestinal cancer: a systematic review and meta-analysis. High visceral fat may be associated with improved OS after radical resection in patients with upper GI cancer. Further studies are needed to confirm these findings and mitigate the risk. |
Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: a meta-analysis of individual participant data. Maternal MMS was associated with a greater GWG % adequacy and total GWG at delivery compared to iron and folic acid only. This finding is consistent with previous results on birth outcomes and will inform policy development and local recommendation of switching routine prenatal iron and folic acid supplements to MMS. |
| J Crohns Colitis |
Perianal Crohn's disease and the development of colorectal and anal cancer: A systematic review and meta-analysis. Half of patients with colorectal cancer and anal cancer were found to have perianal Crohn's. In patients with perianal involvement, there was a higher percentage of anal cancer compared with rectal cancer. These results support the theory that patients with perianal Crohn's are at increased risk for developing colorectal- and anal cancer. Studies, collecting more detailed data about patients and their cancers, are necessary to further specify the disease course. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
Bifidobacterium Animalis Subsp. Lactis Bi-07 Supports Lactose Digestion in Vitro and in Randomized, Placebo and Lactase -controlled Clinical Trials. Bi-07 has high lactase activity, and in 2 clinical trials, it supported lactose digestion in individuals with lactose intolerance. The clinical trials have been registered at with the following identifiers Booster Alpha NCT03659747 ( Omega NCT03814668 ( |
Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial. The GC-MS method allowed robust mapping of diurnal patterns in SCFA concentrations, which were affected by diet, and highlighted the importance of standardizing the timing of SCFA measurements in dietary studies. This trial was registered on the NIHR UK clinical trial gateway and with ISRCTN as ISRCTN43087333. |
Low-carbohydrate vegan diets in diabetes for weight loss and sustainability: a randomized controlled trial. Low-carbohydrate vegan and vegetarian diets reduced body weight, improved glycemic control and blood pressure, but the more plant-based diet had greater potential reduction in greenhouse gas emissions. |
Novel lipid emulsion for total parenteral nutrition based on 18-carbon n-3 fatty acids elicits a superior immunometabolic phenotype in the murine model compared to standard lipid emulsions. We here report the unique anti-inflammatory, insulin-sensitizing and immunity-enhancing properties of a newly developed lipid emulsion designed for TPN use based on 18-carbon n-3 fatty acids. |
Obesity- and Sex-related Metabolism of Arginine and Nitric Oxide in Adults. Alterations in Arg metabolism are present in morbid obesity. Further studies are needed to investigate if these changes could be related to factors such as increased Arg requirement in obesity or metabolic adaptation.Clinical Trial Registry |
The association between TMAO, CMPF and clinical outcomes in advanced CKD; results from the EQUAL study. High CMPF conferred an independent role in health benefits and might even counteract the unfavorable association between TMAO and outcomes. Whether higher circulating CMPF are due to fish consumption, and/or CMPF is a protective factor remains to be verified. |
The effect of 9-mo of formulated whole egg or milk powder food products as meal/snack replacements on executive function in preadolescents: A randomized placebo controlled trial. Consumption of foods with added milk powder as replacements for snacks or meals for 9-mo improves selective attention/inhibitory control in preadolescents. Replacement foods with added whole egg powder does not impact the 9-mo change in preadolescent executive function. |
The Impact of Almonds and Almond Processing On Gastrointestinal Physiology, Luminal Microbiology and Gastrointestinal Symptoms: a Randomized Controlled Trial and Mastication Study. Almond consumption has limited impact on gut microbiota composition but increases butyrate concentrations in adults, suggesting positive alterations to microbiota functionality. Almonds can be incorporated into the diet to increase fiber consumption without triggering gut symptoms. Clinical trial registry ClinicalTrials.gov identifier - NCT03581812. |
| Inflamm Bowel Dis |
Development and Validation of a Japanese Version of the Inflammatory Bowel Disease Self-efficacy Scale and Cross-culture Study in Japan and the United States. The study demonstrates the reliability and validity of the IBD-SESJ. Self-efficacy scores for most items in Japanese patients were lower than those of patients in the United States. Further investigation is required to understand cross-cultural score differences. |
Intestinal Ultrasound to Assess Ulcerative Colitis Disease Activity in Children: External Validation and Comparison of 2 Intestinal Ultrasound Activity Indices. In this cohort, the UC-IUS index performed better than the Civitelli index. The UC-IUS index had both a high sensitivity and specificity in this cohort, when using 1 point as cutoff for a Mayo endoscopic score =2. |
The Impact of Disease Activity on SD and ED in Patients With Inflammatory Bowel Disease. Objective measures of disease activity are not associated with SD or ED in patients with IBD. Clinicians should consider concomitant psychological symptoms contributing to the sexual health of patients with IBD. |
The Pathogenicity and Synergistic Action of Th1 and Th17 Cells in Inflammatory Bowel Diseases. In this review, we focused on Th1 and Th17 cell programs in homeostasis and intestine inflammation and specifically discussed the impact of Th1 and Th17 cell pathogenicity and their synergistic action on the onset and the development of IBD. We hoped to provide some clues for treating IBD. |
| J Crohns Colitis |
Darvadstrocel for complex perianal fistulas in Japanese adults with Crohn's disease: a phase 3 study. The efficacy and tolerability of darvadstrocel in Japanese adult patients with treatment-refractory complex perianal fistulas in Crohn's disease were similar to those observed in the previous European study. |
Paediatric inflammatory bowel disease: a multi-stakeholder perspective to improve development of drugs for children and adolescents. Collaborative action points for al stakeholders are required to make progress and facilitate new drug development for children with inflammatory bowel disease. |
Patients with Inflammatory Bowel Disease Have Heterogeneous Treatment Preferences That Are Largely Determined by the Avoidance of Abdominal Pain and Side Effects [P-POWER IBD Study]. While avoiding abdominal pain, SEs, and serious infections had on average the highest treatment priority, preferences varied between patients. Treatment strategies should consider the trade-offs individuals are willing to make. |
What are the unmet needs and most relevant treatment outcomes according to patients with inflammatory bowel disease? A qualitative patient preference study. This study suggests that IBD drug development and treatment decision-making needs to improve IBD symptoms and adverse events that significantly impact IBD patients' QoL. Furthermore, this study underscores patients need for a shared decision-making process where their desired treatment outcomes and uncertainties are explicitly discussed and considered. |
| Liver Transpl |
Anatomical classification and clinical outcomes of biliary strictures in living donor liver transplantation using right liver grafts. IHBSs are relatively common in right liver LDLTs. Although type 3 IHBSs are rare, they require more intensive care and are associated with poorer graft survival rates than anastomosis strictures and type 2 IHBS. |
Machine learning improves the accuracy of graft weight prediction in living donor liver transplantation. Machine learning can improve the precision of graft weight estimation compared to currently available methods by reducing the frequency of significant errors. The coupling of anthropometric variables to the preoperatively estimated graft volume seems necessary to improve the accuracy of graft weight estimation. |
| Pancreatology |
Efficacy of chemotherapy for patients with metastatic or recurrent pancreatic adenosquamous carcinoma: A multicenter retrospective analysis. This study suggests that combination therapy may be more effective than monotherapy. GnP and FFX showed similar and clinically meaningful efficacy for patients with metastatic or recurrent PASC. |
Impact of recurrent acute pancreatitis on the natural history and progression to chronic pancreatitis. Young age, smoking and alcohol use are seen in patients with RAP who progress to CP. These patients are highly symptomatic and use more healthcare resources, suggestive of an overall a more course compared to those patients who develop CP without preceding RAP. Early identification and counselling of these patients may slow down progression to CP. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
| Liver Transpl |
| Pancreatology |
Between early and established chronic pancreatitis: A proposal of "acinar-ductal hybrid mechanism". The "acinar-ductal hybrid mechanism" may explain the pathological condition and progression of early CP. To diagnose early CP more accurately, it is essential to discover specific biomarkers that can discriminate "early CP" from "acute pancreatitis (AP)/recurrent acute pancreatitis (RAP)" and "established CP." Therapeutic intervention in clinical practices through various new approaches is expected to improve the prognosis of patients with CP. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |